What is Interleukin 6 (IL-6)?

What is Interleukin 6

Interleukin 6 (IL-6) is a pleiotropic cytokine with important functions in both the innate and adaptive immune responses. It is produced by a variety of cell types including macrophages, T cells, B cells, epithelial cells, and endothelial cells. IL-6 signals through a receptor complex composed of the cytokine receptor IL-6R and the signal transducer gp130. IL-6 has been shown to be important in the development of both T helper 1 and T helper 2 responses. It is also involved in the regulation of B cell differentiation, germinal center formation, and plasma cell generation. Innate immune responses IL-6 is an important mediator of the innate immune response. It is produced by macrophages in response to infection, and is involved in the induction of fever. IL-6 has also been shown to be important in the production of acute phase proteins. Acute phase proteins are proteins that are produced in response to inflammation. They include proteins such as C-reactive protein (CRP) and serum amyloid A (SAA). 

CRP is an important marker of inflammation and is used clinically to measure the level of inflammation in patients. SAA is an acute phase protein that is involved in the clearance of lipoproteins from the circulation. IL-6 has also been shown to be important in the development of dendritic cells. Dendritic cells are professional antigen-presenting cells that play a key role in the induction of adaptive immune responses. Adaptive immune responses IL-6 is involved in the development of both T helper 1 and T helper 2 responses. In T helper 1 responses, IL-6 is important in the development of interferon-gamma (IFN-γ) production. IFN-γ is a key cytokine in the innate and adaptive immune responses. It is produced by T cells and natural killer cells, and is involved in the clearance of viruses and the killing of tumour cells. In T helper 2 responses, IL-6 is important in the development of IL-4 production. IL-4 is a key cytokine in the development of allergic responses. It is produced by T cells and mast cells, and is involved in the stimulation of B cells and the production of IgE antibodies. IL-6 is also involved in the regulation of B cell differentiation. 

It has been shown to be important in the development of germinal center formation and plasma cell generation. Germinal centers are important in the development of immunity to infections. Plasma cells are important in the production of antibodies. Clinical significance IL-6 is a cytokine that is important in the development of immunity. It is involved in the production of acute phase proteins, the development of dendritic cells, and the regulation of B cell differentiation. IL-6 is also involved in the development of T helper 1 and T helper 2 responses. IL-6 is a cytokine that is important in the development of immunity. It is involved in the production of acute phase proteins, the development of dendritic cells, and the regulation of B cell differentiation. IL-6 is also involved in the development of T helper 1 and T helper 2 responses. IL-6 is a cytokine that is important in the development of immunity. It is involved in the production of acute phase proteins, the development of dendritic cells, and the regulation of B cell differentiation. IL-6 is also involved in the development of T helper 1 and T helper 2 responses.