Celiac Disease (CD) and Stem Cells

Celiac disease (CD) is an autoimmune enteropathy induced by the ingestion of gluten in genetically susceptible individuals. CD can present at any age but most commonly manifests in early childhood or adolescence. The only currently available treatment is a lifelong gluten-free diet (GFD), which can be difficult to maintain and often results in poor compliance. There is a great need for new therapeutic strategies for the treatment of CD. Mesenchymal stem cells (MSCs) are a type of adult stem cell that can be isolated from a variety of tissues, including the bone marrow, adipose tissue, and cord blood. MSCs have the ability to self-renew and differentiate into a variety of cell types, including osteoblasts, chondrocytes, and adipocytes. MSCs also have immunomodulatory properties and can suppress the immune response. There is increasing evidence to suggest that MSCs may have therapeutic potential in the treatment of autoimmune diseases, including CD. In a mouse model of CD, MSCs were shown to ameliorate intestinal inflammation and improve disease outcomes. MSCs exerted their effects, at least in part, through the production of interleukin-10 (IL-10). IL-10 is a cytokine with anti-inflammatory and immunoregulatory properties. In the mouse model of CD, MSC-derived IL-10 was shown to inhibit the production of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), and to increase the production of the anti-inflammatory cytokine IL-4. The immunomodulatory properties of MSCs make them a promising new treatment for CD. However, there are several challenges that need to be addressed before MSCs can be used clinically. First, it is unclear what the optimal source of MSCs is. Second, the manufacturing process for MSCs needs to be standardized. Finally, the long-term safety of MSC therapy needs to be established.

 "Celiac Disease Symptoms Treated With Stem Cell Therapy." 29 Jun. 2022, https://stemcelldr.com/celiac-disease-symptoms-treated-with-stem-cell-therapy/. Accessed 18 Oct. 2022.

 "Mesenchymal stem cells as potential therapeutic approaches ... - NCBI." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310793/. Accessed 18 Oct. 2022.

 "A Refractory Celiac Patient Successfully Treated With Mesenchymal ...." 14 Apr. 2016, https://www.mayoclinicproceedings.org/article/S0025-6196(16)30004-0/abstract. Accessed 18 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
Myers Cocktail/NAD1N/A