Atherosclerosis and Stem Cells

Atherosclerosis is a disease in which plaque builds up inside your arteries. Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. This limits the flow of oxygen-rich blood to your heart and other organs. Atherosclerosis can lead to heart disease, heart attack, stroke, or vascular disease. Mesenchymal stem cells (MSCs) are a type of adult stem cell that can be found in many tissues, including the bone marrow. MSCs have the ability to self-renew and differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. MSCs are thought to play a role in the repair and regeneration of damaged tissues. MSCs have been shown to reduce the progression of atherosclerosis in animal models. In a study published in the journal, Nature Medicine, MSCs were injected into the abdominal aorta of atherosclerotic mice. The MSCs migrated to the site of injury and differentiated into smooth muscle cells. The MSCs also produced factors that reduced inflammation and promoted the formation of new blood vessels. The results of this study suggest that MSCs may be a promising treatment for atherosclerosis. However, more research is needed to determine if MSCs are safe and effective in humans.

 "The Role of Mesenchymal Stem Cells in Atherosclerosis - NCBI." 8 Sep. 2019, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780166/. Accessed 18 Oct. 2022.

 "Stem Cells and Transplant Arteriosclerosis - AHA Journals." https://www.ahajournals.org/doi/10.1161/circresaha.108.171488. Accessed 18 Oct. 2022.

 "The involving progress of MSCs based therapy in atherosclerosis." 5 Jun. 2020, https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01728-1. Accessed 18 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0002100,000,000
Exosome IV10,000,00060N/A
Total250,000,000