Mesenchymal Stem Cells (MSCs) and Colon Cancer

Mesenchymal stem cells (MSCs) are a type of adult stem cell that can be found in many tissues throughout the body, including the bone marrow, adipose tissue, and even the umbilical cord. MSCs have the ability to differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. In recent years, there has been a great deal of interest in the use of MSCs in the treatment of a variety of diseases, including colon cancer. Colon cancer is the third leading cause of cancer-related deaths in the United States, and it is estimated that there will be over 50,000 deaths from the disease in 2016 alone. The current standard of care for colon cancer involves surgery, chemotherapy, and/or radiation therapy, but these treatments are not always effective, and they can have significant side effects. There is a need for new, more effective treatments for colon cancer, and MSCs may hold promise in this regard. MSCs have been shown to have antitumor effects in a variety of cancer types, including colon cancer. One mechanism by which MSCs may exert their antitumor effects is through the production of cytokines and other immunomodulatory factors. MSCs have also been shown to induce apoptosis in cancer cells, and they can inhibit the growth and metastasis of cancer cells. In addition, MSCs can be used to deliver therapeutic agents directly to cancer cells. There have been a number of clinical trials evaluating the use of MSCs in the treatment of colon cancer. One trial showed that the addition of MSCs to standard chemotherapy improved the overall response rate in patients with metastatic colon cancer. Another trial showed that MSCs could be used to deliver the chemotherapeutic agent irinotecan directly to colon cancer cells, resulting in increased antitumor activity. These trials suggest that MSCs may be a promising new treatment for colon cancer. Despite the promising results of these clinical trials, there are still many unanswered questions about the use of MSCs in the treatment of colon cancer. For example, it is not yet clear what the optimal dose of MSCs is, or how often they should be administered. In addition, it is not clear whether MSCs are more effective when used alone or in combination with other treatments. Further research is needed to answer these questions and to determine the full potential of MSCs in the treatment of colon cancer.

 "Mesenchymal stromal cells (MSCs) and colorectal cancer - NCBI." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312417/. Accessed 20 Oct. 2022.

 "Mesenchymal Stem Cell Administration Attenuates Colon ... - PubMed." https://pubmed.ncbi.nlm.nih.gov/30451398/. Accessed 20 Oct. 2022.

 "Human colorectal cancer-derived mesenchymal stem cells promote ...." 18 Jan. 2018, https://www.nature.com/articles/s41419-017-0176-3. Accessed 20 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV100,000,0002200,000,000
Myers cocktail/NAD1N/A
Total200,000,000