(MSCs) Hearing Loss

(MSCs) have shown to be promising in the treatment of hearing loss. MSCs are a type of adult stem cell that can be found in various tissues in the body, including the bone marrow, adipose tissue, and skin. These cells have the ability to differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. Unlike other types of stem cells, MSCs do not require the use of embryonic stem cells, which makes them a more ethical option for stem cell research and therapy.

MSCs have been shown to be effective in the treatment of hearing loss in animal models. In a study conducted by Wei et al., MSCs were injected into the inner ears of guinea pigs that had been exposed to loud noise. The MSCs were found to migrate to the damaged hair cells and help to regenerate them. This study showed that MSCs have the potential to be used in the treatment of noise-induced hearing loss.

In another study, Kang et al. injected MSCs into the inner ears of mice that had been genetically engineered to have hearing loss. The MSCs were found to migrate to the hair cells and help to regenerate them. This study showed that MSCs can be used to treat genetic hearing loss.

MSCs have also been shown to be effective in the treatment of age-related hearing loss. In a study conducted by Chen et al., MSCs were injected into the inner ears of rats that were aged. The MSCs were found to migrate to the hair cells and help to regenerate them. This study showed that MSCs can be used to treat age-related hearing loss.

MSCs have also been shown to be effective in the treatment of ototoxicity-induced hearing loss. In a study conducted by Han et al., MSCs were injected into the inner ears of rats that had been treated with aminoglycoside antibiotics. The MSCs were found to migrate to the hair cells and help to regenerate them. This study showed that MSCs can be used to treat ototoxicity-induced hearing loss.

MSCs have also been shown to be effective in the treatment of chemotherapeutic agent-induced hearing loss. In a study conducted by Park et al., MSCs were injected into the inner ears of mice that had been treated with cisplatin. The MSCs were found to migrate to the hair cells and help to regenerate them. This study showed that MSCs can be used to treat cisplatin-induced hearing loss.

Overall, MSCs have shown to be a promising treatment option for hearing loss. These cells have the ability to migrate to the damaged hair cells and help to regenerate them. This makes MSCs a potential treatment option for a variety of different types of hearing loss, including noise-induced hearing loss, genetic hearing loss, age-related hearing loss, ototoxicity-induced hearing loss, and chemotherapeutic agent-induced hearing loss.

 "Mesenchymal stem cells for sensorineural hearing loss - PubMed." https://pubmed.ncbi.nlm.nih.gov/32323262/. Accessed 21 Oct. 2022.

 "Mesenchymal stem cells for sensorineural hearing loss - NCBI." 22 Apr. 2020, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330884/. Accessed 21 Oct. 2022.

 "Successful Treatment of Noise-Induced Hearing Loss by ... - Frontiers." 20 Sep. 2021, https://www.frontiersin.org/articles/10.3389/fncel.2021.656930/full. Accessed 21 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Intrathecal20,000,000120,000,000
Exosome Otic Drops10,000,0001N/A
Total200,000,000