Endometriosis and Stem Cells

Endometriosis is a chronic, degenerative disease characterized by the presence of endometrial tissue outside of the uterus. This tissue is often found in the pelvic cavity, but can also be found in other areas of the body such as the lungs, brain, and even the abdominal cavity. While the exact cause of endometriosis is unknown, it is believed to be the result of a combination of hormonal and immunological factors. The most common symptom of endometriosis is pelvic pain, which is often severe and can be debilitating. Other symptoms include abnormal bleeding, fatigue, and gastrointestinal problems. There is no cure for endometriosis, but there are treatments available that can help to manage the symptoms and improve the quality of life for those affected by the disease. One such treatment is mesenchymal stem cell therapy. Mesenchymal stem cells (MSCs) are a type of adult stem cell that can be found in many tissues throughout the body. MSCs have the ability to differentiate into a variety of cell types, including bone, muscle, and fat cells. They also have anti-inflammatory and immunomodulatory properties. MSC therapy has shown promise in the treatment of a variety of diseases, including endometriosis. In a small clinical trial, MSC therapy was found to be safe and effective in the treatment of endometriosis-related pelvic pain. MSCs were injected into the pelvic cavity of eight women with endometriosis. The women receiving MSC therapy reported a significant reduction in pelvic pain, as well as improvements in quality of life. These results are encouraging, but larger clinical trials are needed to confirm the efficacy of MSC therapy in the treatment of endometriosis. MSC therapy holds great promise for the treatment of endometriosis and other chronic diseases. MSCs are readily available and can be easily isolated from a variety of tissues. They are also relatively easy to culture and expand in vitro. In addition, MSCs can be administered locally, which reduces the risk of side effects. However, there are still some challenges that need to be addressed before MSC therapy can be used routinely in the clinic. For example, the long-term safety and efficacy of MSC therapy need to be established in larger clinical trials. Additionally, the optimal route of administration and dose of MSCs need to be determined. Despite these challenges, MSC therapy holds great promise for the treatment of endometriosis and other chronic diseases. MSCs are a promising new treatment option that has the potential to improve the quality of life for those affected by these diseases.

 "Stem Cells and the Pathogenesis of Endometriosis - PMC - NCBI." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107843/. Accessed 21 Oct. 2022.

 "STEM CELLS IN ENDOMETRIUM AND THEIR ROLE IN THE ... - NCBI." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076708/. Accessed 21 Oct. 2022.

 "Endometrial stem/progenitor cells and their roles in immunity ...." 23 Aug. 2021, https://stemcellres.biomedcentral.com/articles/10.1186/s13287-021-02526-z. Accessed 21 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0001N/A
PeriVaginal50,000,000150,000,000
Intrauterine50,000,000150,000,000
Total250,000,000