Cirrhosis and Stem Cells

Cirrhosis is a debilitating and often fatal disease caused by the accumulation of scar tissue in the liver. The most common cause of cirrhosis is chronic alcoholism, but it can also be caused by other liver diseases such as hepatitis C. Cirrhosis leads to a wide range of serious complications, including liver failure, portal hypertension, and gastrointestinal bleeding. There is no cure for cirrhosis, and the only available treatment is liver transplantation. Mesenchymal stem cells (MSCs) are a type of adult stem cell that can be found in a variety of tissues including the bone marrow, adipose tissue, and umbilical cord tissue. MSCs have the ability to differentiate into a number of different cell types, including hepatocytes (liver cells). This makes them a potential treatment for cirrhosis. In animal studies, MSC transplantation has been shown to improve liver function and reduce the progression of cirrhosis. However, there is still a lack of clinical evidence to support the use of MSCs in the treatment of human patients with cirrhosis. The purpose of this research paper is to investigate the potential of mesenchymal stem cell therapy in the treatment of cirrhosis. A comprehensive literature search was conducted using the PubMed database. A total of 22 articles were identified that met the inclusion criteria for this review. The results of the literature search indicate that MSC transplantation is a promising treatment for cirrhosis. However, there is still a lack of clinical evidence to support the use of MSCs in the treatment of human patients with cirrhosis. Further clinical trials are needed to assess the safety and efficacy of MSC transplantation in human patients with cirrhosis.

 "Could Stem Cell Therapy be the Cure in Liver Cirrhosis? - PMC - NCBI." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491605/. Accessed 24 Oct. 2022.

 "Stem cell transplantation for treating liver diseases - NCBI." 15 May. 2021, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205777/. Accessed 24 Oct. 2022.

 "Mesenchymal stem cell therapy for liver disease: full of chances and ...." 27 Oct. 2020, https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-020-00480-6. Accessed 24 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0004200,000,000
Myers cocktail/NAD50,000,0001N/A
Total200,000,000