Mesenchymal Stem Cells (MSCs) and Arthritis

Arthritis is a debilitating condition that affects millions of people worldwide. The most common type of arthritis, osteoarthritis, is caused by the wear and tear of the cartilage that cushions the ends of the bones in our joints. This can lead to pain, stiffness, and inflammation. Mesenchymal stem cells (MSCs) are a type of adult stem cell that can differentiate into a variety of cell types, including cartilage cells. MSCs have been shown to be effective in treating a number of different diseases and conditions, including arthritis. MSCs can be injected into the joint to repair damaged cartilage and reduce pain and inflammation. In one study, MSCs were injected into the knees of patients with osteoarthritis. The patients injected with MSCs had significantly less pain and better function than those who did not receive the treatment. MSCs can also be used to create a scaffold on which new cartilage can grow. In one study, MSCs were seeded onto a scaffold and then transplanted into the joints of rats with osteoarthritis. The rats that received the MSC-seeded scaffold had significantly less cartilage damage and less pain than those that did not receive the treatment. MSCs are a promising treatment for arthritis and other diseases and conditions. However, more research is needed to determine the long-term efficacy and safety of MSCs.

 "Mesenchymal stem cells in osteoarthritis therapy: a review - NCBI." 15 Feb. 2021, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868850/. Accessed 24 Oct. 2022.

 "Mesenchymal Stem Cell Therapy for Osteoarthritis: The Critical Role ...." 29 Jan. 2019, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361779/. Accessed 24 Oct. 2022.

 "A narrative review of mesenchymal stem cells effect on osteoarthritis." 15 Jul. 2022, https://aoj.amegroups.com/article/view/7018/html. Accessed 24 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0001N/A
Intra-articular


50,000,000150,000,000
Tendon50,000,000150,000,000
Total250,000,000