Glenohumeral Arthritis and Mesenchymal Stem Cells

glenohumeral-arthritis-post

Glenohumeral arthritis is a type of arthritis that affects the shoulder joint. The shoulder joint is a ball-and-socket joint that allows the arm to move in a wide range of motion. The ball is called the humeral head, and it fits into a socket called the glenoid. The glenoid is held in place by a rim of bone called the labrum. The joint is surrounded by a lubricating sac called the synovium. The synovium produces a fluid that helps reduce friction in the joint. The joint is also surrounded by muscles, ligaments, and tendons that hold it in place and allow it to move. Glenohumeral arthritis is a degenerative disease that occurs when the cartilage that covers the surfaces of the bones in the joint breaks down. This can happen due to wear and tear injury, or disease. When the cartilage breaks down, the bones rub against each other, causing pain, stiffness, and loss of movement in the joint. Glenohumeral arthritis is treated with a combination of medication, physical therapy, and surgery. Medications, such as anti-inflammatory drugs and painkillers, can help reduce pain and inflammation. Physical therapy can help stretch and strengthen the muscles around the joint. Surgery may be necessary to repair or replace the damaged joint. Mesenchymal stem cells (MSCs) are a type of adult stem cell that can be found in many tissues, including the bone marrow. MSCs have the ability to differentiate into many different types of cells, including cartilage cells. Injecting MSCs into the joint has been shown to improve the symptoms of glenohumeral arthritis. MSCs can help to repair the damaged cartilage and improve the function of the joint. Injecting MSCs into the joint is a safe and effective treatment for glenohumeral arthritis.

 

 "Glenohumeral Osteoarthritis: The Role for Orthobiologic Therapies." 4 Feb. 2020, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055935/.

 "Mesenchymal stem cell therapy for osteoarthritis: current perspectives." 28 Aug. 2015, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559256/.

 "Mesenchymal Stem Cells for Shoulder Tendon and Arthritis." 9 Sep. 2022, https://www.shoulderdoc.co.uk/article/1716.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0001N/A
Intra-articular50,000,00050,000,000
Total200,000,000