Mesenchymal Stem Cells (MSCs) and Meniscal Tears

Mesenchymal stem cells (MSCs) are a type of adult stem cell that can be found in many tissues throughout the body, including the bone marrow, fat, and connective tissue. MSCs have the ability to self-renew and differentiate into many different cell types, including cartilage, bone, and muscle. In recent years, there has been increasing interest in the use of MSCs to treat meniscal tears, as they offer a potential alternative to traditional treatments such as surgery or joint replacement. MSCs can be injected directly into the knee joint, where they can then differentiate into new cartilage cells and help to repair the damaged meniscus. There are several clinical trials currently underway that are investigating the use of MSCs to treat meniscal tears, and the results so far have been promising. In one study, patients who received MSC injections showed significant improvements in pain and function, and there was also evidence of new cartilage growth. These results suggest that MSCs could potentially be used to treat meniscal tears without the need for surgery, which would be a major advance in the treatment of this condition. However, more research is needed to confirm the safety and efficacy of this treatment before it can be widely adopted.

 "Potential use of mesenchymal stem cells in human meniscal repair." 23 Mar. 2017, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367609/. Accessed 24 Oct. 2022.

 "In Vivo Studies of Mesenchymal Stem Cells in the Treatment of ...." 8 Nov. 2021, https://pubmed.ncbi.nlm.nih.gov/34747566/. Accessed 24 Oct. 2022.

 "Meniscus repair: up-to-date advances in stem cell-based therapy." 16 May. 2022, https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-02863-7. Accessed 24 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0001N/A
Meniscus50,000,000150,000,000
Intra-articular50,000,000150,000,000
Total250,000,000