Patellar Tendon and Stem Cells

The patellar tendon is a band of tissue that connects the kneecap to the shinbone. The tendon helps the knee joint move by providing stability and transferring force from the muscles of the thigh to the bones of the lower leg. The patellar tendon is also known as the knee extensor tendon because it helps straighten the leg when the knee is extended. The patellar tendon is surrounded by a thin layer of tissue called the synovial sheath. The synovial sheath helps to reduce friction between the tendon and the surrounding tissues. The synovial sheath also contains a small amount of fluid that helps to lubricate the tendon and keep it healthy. The patellar tendon is made up of two types of tissue: collagen and elastin. Collagen is a strong, fibrous protein that gives the tendon its strength. Elastin is a more elastic protein that allows the tendon to stretch and return to its original shape. The patellar tendon is subject to a lot of wear and tear due to the forces it must withstand during activities such as walking, running, and jumping. This can eventually lead to the development of small tears in the tendon. These tears can cause the tendon to become weak and less elastic. If the patellar tendon becomes too weak, it can rupture (tear completely). A patellar tendon rupture is a serious injury that can cause pain and disability. Surgery is often required to repair the tendon. Mesenchymal stem cells (MSCs) are a type of cell that can be found in many tissues of the body, including the bone marrow, adipose tissue, and cord blood. MSCs have the ability to self-renew (make more of themselves) and differentiate (change into different types of cells). MSCs were first isolated from the bone marrow in the early 1960s. Since then, they have been studied extensively for their potential use in regenerative medicine. MSCs have been shown to be effective in the treatment of a variety of injuries and diseases, including heart attack, stroke, diabetes, and arthritis. MSCs are currently being studied as a potential treatment for patellar tendon rupture. The goal of this research is to see if MSCs can be used to repair the tendon and improve its function. MSCs are injected into the site of the patellar tendon rupture. The MSCs then begin to differentiate into cells that make up the tendon. These cells lay down new collagen and elastin fibers, which gradually repair the tendon. The use of MSCs to treat patellar tendon rupture is still in the early stages of research. However, the results of the few studies that have been conducted are promising. MSCs have the potential to improve the function of the patellar tendon and reduce the risk of re-rupture.

 "Patellar Tendonitis and the Power of Stem Cell Therapy." 24 May. 2018, https://www.spinecorrectioncenter.com/patellar-tendonitis-and-the-power-of-stem-cell-therapy/. Accessed 24 Oct. 2022.

 "Treatment of Chronic Patellar Tendinopathy with Autologous Bone ...." 18 Dec. 2011, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246763/. Accessed 24 Oct. 2022.

 "Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon ...." 30 Mar. 2018, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933298/. Accessed 24 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0001N/A
Patellar tendon50,000,000150,000,000
Total200,000,000