Mesenchymal Stem Cells (MSCs) and Rotator Cuff Tears

Mesenchymal stem cells (MSCs) are a type of adult stem cell that can be found in many tissues throughout the body, including the bone marrow, adipose tissue, and peripheral blood. MSCs have the ability to self-renew and differentiate into a variety of cell types, including osteoblasts, chondrocytes, and adipocytes. The use of MSCs to treat rotator cuff tears is a promising new treatment option that has the potential to improve the outcomes of surgery. MSCs can be injected into the site of the rotator cuff tear and have the ability to differentiate into new tendons and muscle cells. This can help to repair the rotator cuff tear and improve the function of the shoulder. There are a few clinical studies that have been conducted to assess the efficacy of MSCs in the treatment of rotator cuff tears. The results of these studies are promising, but more research is needed to confirm the efficacy of this treatment. MSCs are a promising new treatment option for rotator cuff tears that has the potential to improve the outcomes of surgery.

 "Intratendinous Injection of Mesenchymal Stem Cells for ... - PubMed." https://pubmed.ncbi.nlm.nih.gov/31805388/. Accessed 17 Oct. 2022.

 "Regeneration of a full-thickness defect of rotator cuff tendon with ...." 7 Sep. 2020, https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01906-1. Accessed 17 Oct. 2022.

 "Advances in Stem Cell Therapies for Rotator Cuff Injuries - Frontiers." 25 Apr. 2022, https://www.frontiersin.org/articles/10.3389/fbioe.2022.866195/full. Accessed 17 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0001N/A
Intra-articular50,000,000150,000,000
Affected Tendon50,000,000150,000,000
Total250,000,000