Mesenchymal Stem Cells (MSCs) Sciatica

Mesenchymal stem cells (MSCs) are a type of multipotent stromal cell that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells). MSCs can be isolated from a variety of tissue sources, including bone marrow, adipose tissue, and cord blood. MSCs have shown promise in the treatment of a variety of diseases and injuries, including bone fractures, tendinitis, and cartilage damage. In addition, MSCs have been shown to be effective in the treatment of sciatica, a condition characterized by pain in the lower back and legs. There are a number of clinical trials currently underway to evaluate the safety and efficacy of MSCs in the treatment of sciatica. In one study, patients with sciatica were treated with a single injection of MSCs into the affected area. The results of the study showed that the MSCs were safe and well-tolerated and that the majority of patients experienced significant improvements in their symptoms. Another clinical trial is evaluating the use of MSCs in the treatment of patients with chronic low back pain. In this study, patients will receive injections of MSCs into the affected area every three months for a period of two years. The goal of this trial is to determine if the MSCs are safe and effective in the long-term treatment of chronic low back pain. The use of MSCs in the treatment of sciatica and other conditions is a promising area of research. The results of clinical trials will help to determine the safety and efficacy of MSCs in the treatment of these conditions.

 "Mesenchymal Stem Cells Enhance Nerve Regeneration in a Rat ...." 11 Aug. 2016, https://www.nature.com/articles/srep31306. Accessed 24 Oct. 2022.

 "Differentiated mesenchymal stem cells for sciatic nerve injury." https://pubmed.ncbi.nlm.nih.gov/21327572/. Accessed 24 Oct. 2022.

 "Human Wharton's Jelly Mesenchymal Stem Cell-Mediated ... - PubMed." 31 Aug. 2020, https://pubmed.ncbi.nlm.nih.gov/32878186/. Accessed 24 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0002N/A
Exosome IV10,000,00060N/A
Intrathecal (site of injury)50,000,000150,000,000
Spinal Level/Intra discal50,000,000150,000,000
Total250,000,000