Stress Fracture and Mesenchymal Stem Cells

A stress fracture is a tiny crack in a bone that occurs due to repetitive or excessive force, such as from overuse during running or other high-impact activities. Stress fractures are most common in the lower limbs, particularly in the shin and foot. Mesenchymal stem cells (MSCs) are a type of adult stem cell that can differentiate into multiple cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), and adipocytes (fat cells). MSCs have the ability to repair and regenerate damaged tissue, making them a potential treatment for stress fractures. MSCs can be isolated from a variety of tissues, including adipose tissue (fat), bone marrow, and umbilical cord blood. Once isolated, they can be expanded in culture and used to treat a variety of diseases and conditions. The use of MSCs in the treatment of stress fractures is a relatively new area of research. However, there have been a few small clinical trials that have shown promising results. In a clinical trial involving 24 patients with tibial stress fractures, MSCs were injected into the fracture site. The patients were followed for six months, and the results showed that MSCs improved fracture healing and reduced pain levels. Another clinical trial involving 42 patients with tibial stress fractures found that the use of MSCs improved fracture healing and reduced the need for surgery. The results of these clinical trials suggest that MSCs may be a safe and effective treatment for stress fractures. However, larger and more long-term studies are needed to confirm these findings. MSCs are a promising new treatment for stress fractures. However, more research is needed to determine their safety and efficacy.

 "Effect of mesenchymal stem cells on biomechanics of stress fracture ...." https://pubmed.ncbi.nlm.nih.gov/34803001/. Accessed 21 Oct. 2022.

 "Role of mesenchymal stem cells in bone regeneration and fracture ...." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843208/. Accessed 21 Oct. 2022.

 "Effect of Bone-Marrow-Derived Mesenchymal Stem Cells on the ...." 17 Sep. 2021, https://www.liebertpub.com/doi/10.1089/jir.2021.0093. Accessed 21 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0001N/A
Local50,000,000150,000,000
Total200,000,000