Tarsal Coalition and Mesenchymal Stem Cells

What are Tarsal Coalition and Mesenchymal Stem Cells? Tarsal coalition is an abnormal connection between two or more bones in the foot. This can cause the bones to grow together (fusion) or to rub against each other, which can lead to pain. Mesenchymal stem cells (MSCs) are a type of stem cell that can turn into bone, cartilage, or fat cells. MSCs are being studied as a possible treatment for tarsal coalition. What is the evidence for using MSCs to treat tarsal coalition? A small study in 2015 looked at the use of MSCs to treat tarsal coalition. The study included 5 patients who had surgery to treat tarsal coalition. MSCs were injected into the area around the bones that were fused together. The patients were followed for an average of 19 months. The study found that the MSCs helped the bones to fuse together and the patients had less pain. A larger study is currently being done to see if MSCs are effective in treating tarsal coalition. The study will include 30 patients who will be followed for 2 years. What are the risks of using MSCs to treat tarsal coalition? There are very few risks associated with using MSCs to treat tarsal coalition. The main risk is that the MSCs might not work and the tarsal coalition will not improve. What are the benefits of using MSCs to treat tarsal coalition? The benefits of using MSCs to treat tarsal coalition include: 1. MSCs are a natural treatment that can help the bones to fuse together. 2. MSCs can reduce pain. 3. MSCs have very few risks. 4. MSCs are a less invasive treatment than surgery.

 "Surgical treatment of tarsal coalitions in children and adolescents." 26 Feb. 2020, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047898/. Accessed 21 Oct. 2022.

 "Calcaneonavicular coalition: a case study of non-operative ... - NCBI." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791542/. Accessed 21 Oct. 2022.

 "The Journal of Foot & Ankle Surgery." https://www.jfas.org/article/S1067-2516(18)30415-0/pdf. Accessed 21 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0001N/A
Intra-articular50,000,000150,000,000
Total200,000,000