Mesenchymal Stem Cells (MSCs) and Tendon Tears

Mesenchymal stem cells (MSCs) are a type of adult stem cell that can be found in various tissues throughout the body, including the bone marrow, fat, and blood. MSCs are multipotent, meaning they can differentiate into multiple cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), and adipocytes (fat cells). In addition to their ability to differentiate into multiple cell types, MSCs also have a high proliferative potential, meaning they can divide and self-renew for long periods of time. The regenerative properties of MSCs make them a promising treatment for tendon tears. When a tendon tears, the ends of the tendon fibers pull away from each other, which can damage the surrounding blood vessels and nerves. This damage can lead to the formation of scar tissue, which can prevent the tendon from healing properly. MSCs can be injected into the site of a tendon tear to help promote healing. The MSCs will differentiate into the various cell types needed to repair the damage, including blood vessels, nerve cells, and tendon cells. In addition, the MSCs will help to reduce inflammation and prevent the formation of scar tissue. There are a number of clinical trials currently underway to evaluate the efficacy of MSCs in the treatment of tendon tears. The results of these trials will help to determine whether MSCs are an effective treatment for this condition.

 "Mesenchymal Stem Cells Empowering Tendon Regenerative ... - NCBI." 19 Jun. 2019, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627139/. Accessed 24 Oct. 2022.

 "Mesenchymal Stem Cells for Treatment of Tendon and Ligament ...." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780758/. Accessed 24 Oct. 2022.

 "Mesenchymal Stem Cell Use in Acute Tendon Injury - MDPI." 22 Aug. 2022, https://www.mdpi.com/2306-5354/9/8/407/pdf. Accessed 24 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0001N/A
Tendon


50,000,000150,000,000
Total200,000,000