Mesenchymal Stem Cells (MSCs) and Tenosynovitis

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Mesenchymal stem cells (MSCs) are a type of adult stem cell that can be found in many tissues throughout the body, including the bone marrow, adipose tissue, and even umbilical cord blood. MSCs have the ability to self-renew and differentiate into a variety of cell types, making them a promising tool for regenerative medicine. Tenosynovitis is a condition that results in the inflammation of the tendon sheath, the layer of tissue that surrounds and protects tendons. Tenosynovitis can be caused by a variety of different things, including overuse, injury, or infection. The inflammation of the tendon sheath can lead to pain, stiffness, and loss of movement in the affected area. MSCs have been shown to be effective in treating a variety of different conditions, including tenosynovitis. In a study published in 2015, MSCs were injected into the tendon sheaths of rats with tenosynovitis. The rats were then monitored for eight weeks. The results of the study showed that the rats that received the MSC injection had significantly less inflammation and pain than the rats that did not receive the injection. MSCs are a promising treatment option for tenosynovitis because they have the ability to reduce inflammation and pain while promoting the regeneration of tissue.

 "Mesenchymal Stem Cells Use in the Treatment of Tendon Disorders." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435464/. Accessed 21 Oct. 2022.

 "Mesenchymal stem cell applications to tendon healing - PMC - NCBI." 16 Oct. 2012, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666516/. Accessed 21 Oct. 2022.

 "Mesenchymal Stem Cell Therapy for Osteoarthritis: The Critical Role ...." 11 Jan. 2019, https://www.frontiersin.org/articles/10.3389/fbioe.2019.00009/full. Accessed 21 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0001N/A
Intra-articular

5,000,00015,000,000
Tendon(sheath)5,000,00015,000,000
Total160,000,000