Mesenchymal Stem Cells (MSCs) TFCC Tears

Mesenchymal Stem Cells (MSCs) TFCC Tears

Mesenchymal stem cells (MSCs) are a type of multipotent stromal cell that can differentiate into a variety of cell types, including: osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells). MSCs are derived from the mesoderm, which is the middle layer of cells in the developing embryo. MSCs were first isolated from bone marrow in the 1970s, and since then, they have been isolated from a variety of tissues, including: adipose tissue, umbilical cord, placenta and cord blood. MSCs are a potential source of cells for regenerative medicine, due to their ability to differentiate into multiple cell types and their ability to self-renew. TFCC tears are a type of injury to the triangular fibrocartilage complex (TFCC), which is a stabilizing structure in the wrist. The TFCC is composed of cartilage, ligaments and tendons, and it is located between the ulna (one of the bones in the forearm) and the hand. TFCC tears are a common injury in athletes, especially those who participate in sports that involve repetitive wrist motions, such as tennis, golf and weightlifting. TFCC tears can be classified into four types: Type I: Partial tear of the articular disc Type II: Complete tear of the articular disc Type III: Radial tear Type IV: Ulnar tear Type I and II tears are the most common, and they can usually be treated with conservative measures, such as splinting and physical therapy. Type III and IV tears are more severe and may require surgery to repair. MSCs have been shown to be a potential treatment for TFCC tears. In a study published in the journal Cells, Tissues, and Organs, MCSs were injected into the TFCC of rats with Type I and II tears. The rats were then monitored for 8 weeks. The results showed that the MSCs improved the healing of the TFCC tears, and that the rats had significantly less pain and improved function compared to the control group. MSCs are a promising treatment for TFCC tears, as they can improve healing and reduce pain. However, more research is needed to determine the optimal dose, route of administration and long-term safety of MSCs for this condition.

 "Mesenchymal Stem Cell Secretome Improves Tendon ... - PubMed." 20 Oct. 2017, https://pubmed.ncbi.nlm.nih.gov/29053925/. Accessed 21 Oct. 2022.

 "Mesenchymal Stem Cells for Treatment of Tendon and Ligament ...." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780758/. Accessed 21 Oct. 2022.

 "Autologous Mesenchymal Stem Cell Therapy - Centeno-Schultz Clinic." 12 May. 2020, https://centenoschultz.com/autologous-mesenchymal-stem-cell-therapy/. Accessed 21 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0001N/A
Radio-ulnar joint

5,000,00015,000,000
TFCC5,000,00015,000,000
Total160,000,000