Stem Cells and Thoracic Vertebrae

The intervertebral disc is a unique structure in the human body that acts as a shock absorber between the vertebrae. The disc is made up of an outer layer of tough, fibrous tissue (the annulus fibrosus) and a gel-like inner core (the nucleus pulposus). The annulus fibrosus provides strength and stability to the disc, while the nucleus pulposus acts as a cushion to absorb the impact of body weight and movement. Disc herniation occurs when the inner core of the disc leaks out through a tear in the annulus fibrosus. This can cause pain, numbness, and weakness in the affected area. Disc herniation is a common condition that can be treated with conservative measures such as pain medication and physical therapy. In some cases, surgery may be necessary to remove the herniated disc and relieve the pressure on the nerve. Mesenchymal stem cells (MSCs) are a type of adult stem cell that can be found in many tissues of the body, including the bone marrow, adipose tissue, and umbilical cord. MSCs have the ability to self-renew and differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), and adipocytes (fat cells). The use of MSCs for the treatment of disc herniation is a promising new therapy that is currently being studied in clinical trials. MSCs have the ability to migrate to the site of injury and promote healing by secreting growth factors and cytokines. Additionally, MSCs can differentiate into the cells of the annulus fibrosus and nucleus pulposus, which may help to repair the damaged disc. The potential use of MSCs for the treatment of disc herniation is an exciting new development in the field of regenerative medicine. However, more research is needed to determine the safety and efficacy of this treatment.

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 "Stem cell therapy in discogenic back pain - PMC - NCBI." 22 Sep. 2019, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989932/

 "Stem cell treatment after spinal cord injury: The next steps." 27 Jun. 2020, https://www.mayoclinic.org/medical-professionals/neurology-neurosurgery/news/stem-cell-treatment-after-spinal-cord-injury-the-next-steps/mac-20488605

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0003150,000,000
Myers cocktail/NAD50,000,0002N/A
Exosome IV10,000,00060N/A
Intrathecal (site of injury)50,000,000150,000,000
Spinal Level/Intra discal50,000,000150,000,000
Total250,000,000