Stem Cells and Smoking

Smoking is a risk factor for a number of diseases and conditions, including cancer, heart disease, stroke, and chronic obstructive pulmonary disease (COPD). The harmful effects of smoking are well-documented, but the mechanisms by which smoking increases the risk for these diseases are not fully understood. One potential mechanism is through the effect of smoking on mesenchymal stem cells (MSCs). MSCs are a type of stem cell that can differentiate into a variety of cell types, including bone, cartilage, and fat cells. MSCs are found in a number of different tissues, including the bone marrow, adipose tissue, and umbilical cord. Smoking has been shown to have a negative effect on MSCs, including reducing their proliferation and differentiation potential. In addition, smoking has been shown to induce DNA damage in MSCs. This DNA damage can lead to genetic mutations that may be passed on to daughter cells, potentially increasing the risk of cancer. Smoking has also been shown to reduce the expression of a number of genes that are important for the maintenance and repair of DNA. Taken together, these effects of smoking on MSCs could potentially contribute to the development of smoking-related diseases. More research is needed to confirm the role of MSCs in the development of these diseases, but the current evidence suggests that smoking has a negative effect on these cells that could contribute to the development of smoking-related diseases.

 "Stem cell niches exposed to tobacco smoke - PubMed." https://pubmed.ncbi.nlm.nih.gov/23421093/. Accessed 24 Oct. 2022.

 "Effects of nicotine on the translation of stem cell therapy - PMC - NCBI." 3 Jul. 2020, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466930/. Accessed 24 Oct. 2022.

 "Regenerative power of fat-derived stem cells impaired by smoking." 17 Apr. 2018, https://ufhealth.org/news/2018/regenerative-power-fat-derived-stem-cells-impaired-smoking. Accessed 24 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
IV50,000,0004200,000,000
Myers cocktail/NAD50,000,0001N/A
Possibly Inhalational
exosomes


100,000,0001100,000,000
Total300,000,000