Sacroiliitis and Stem Cells

Sacroiliitis is a condition that refers to the inflammation of one or both of the sacroiliac joints. These joints are located at the base of the spine where the sacrum meets the iliac bones. The sacroiliac joints are responsible for absorbing shock and transferring weight from the upper body to the lower extremities. When they become inflamed, they can cause a great deal of pain and disability. There are a number of different causes of sacroiliitis, but the most common is arthritis. Arthritis is a general term used to describe any condition that causes inflammation in the joints. There are many different types of arthritis, but the two most common types that affect the sacroiliac joints are rheumatoid arthritis and ankylosing spondylitis. Other causes of sacroiliitis include trauma, infection, and pregnancy. Sacroiliitis is usually diagnosed based on a combination of symptoms, medical history, and physical examination. X-rays, MRIs, and CT scans can also be helpful in making the diagnosis. Treatment of sacroiliitis typically includes a combination of pain medication, physical therapy, and, in some cases, surgery.

One promising new treatment for sacroiliitis is the use of mesenchymal stem cells (MSCs). MSCs are a type of adult stem cell that can be isolated from a variety of tissues and is the most commonly used to treat sacroiliitis. MSCs have the ability to differentiate into a number of different cell types, including bone, cartilage, and muscle cells. This makes them a potential treatment for a number of different conditions, including sacroiliitis. This is mainly done by the stem cells being injected directly to the affected area of sacroiliitis. The use of MSCs in the treatment of sacroiliitis is still in the early stages of research. However, there have been a few small studies that have shown promising results showing that the main function of the stem cells with this treatment is to produce anti-inflammatory molecules. One study found that the use of MSCs was associated with a significant reduction in pain and an improvement in function in patients with sacroiliitis. Another study found that the use of MSCs improved the quality of life in patients with sacroiliitis.

The use of MSCs in the treatment of sacroiliitis is a promising new treatment option. However, larger and more well-designed studies are needed to confirm the efficacy of this treatment.

 “Treatment for Sacroiliac Joint Dysfunction.” 20 Aug. 2020, Accessed 24 Oct. 2022.

 “Stem Cell Therapy and other non-surgical treatments for sacroiliac ….” Accessed 24 Oct. 2022.

 “Sacroilitis (SI Joint Dysfunction) – Regen Orthopedics.” 8 May. 2018, Accessed 24 Oct. 2022.

The information below is the recommended stem cell therapy protocol for this condition 

Route of AdministrationDoseTime (Days)Total Cells
Myers cocktail/NAD50,000,0001N/A
Intra-articular/per side50,000,000150,000,000